We’ve barely had any time to catch our breath from that bonkers NFL Sunday, but we’ve still got a Monday Night Football doubleheader to close out Week 2. In the first game of the night, the Super Bowl-favorite Buffalo Bills will play host to the Tennessee Titans.

Let’s dive into the matchup from a betting perspective and try to make some money with a few best bets for Bills-Titans.

Bills vs. Titans odds, spread, prediction

Spread: Bills -10
Total: 47.5
Moneyline: Bills -450, Titans +350

The Bills are widely regarded as the best team in the NFL early on in the season, so it’s no surprise they’re massive favorites against the 0-1 Titans at home. Buffalo is currently a 10-point favorite in the game, with the total sitting at 47.5.

A majority of bettors are expecting the Bills to dominate from the opening kick and cover this spread easily, but I’m not so sure. The Titans knocked off the Bills in Nashville last season, as Derrick Henry went off for 143 rushing yards and three touchdowns. King Henry should be the star of the show once again for Tennessee Monday night.

I’m not a believer in this Titans roster as a whole, but I am a firm believer in Mike Vrabel as a dog. Tennessee has been an underdog of three points or more 28 times in the Vrabel era. The Titans are 19-9 straight up and 20-8 against the spread in those games. After a frustrating loss in Week 1, I expect Vrabel to coach aggressively and dive deep in the playbook to keep up with Buffalo’s high-powered offense.

I see the Titans keeping this one close to the end, but I trust Josh Allen to find a way in the fourth quarter and squeak out a victory.

Prediction: Bills 23, Titans 20

Bills vs. Titans best bets

Bills-Titans betting at @BetMGM @BuffaloBills open -9.5, now -10
▪️ 59% of bets, 69% of money on Bills

Total open 49.5, now 47.5
▪️ 40% of bets, 51% of money on Under@Titans open +325, now +350
▪️ 61% of bets, 38% of money on Titans

— John Ewing 🦁 (@johnewing) September 19, 2022

Titans +10 (-110)

I’ve already explained why I like the Titans to keep it close in Buffalo Monday night, so I’ll take the fighting Vrabel’s +10. Don’t be surprised if they pull off the upset.

Dawson Knox anytime touchdown (+160)

Dawson Knox scored 11 touchdowns in 17 starts last season, but he saw just two targets in Week 1 against the Rams. I think the Bills make it a point to get their tight end more involved in Week 2, especially in the red zone.

With Gabriel Davis questionable to play due to an ankle injury, Knox could be Allen’s No. 2 target in the game.

Austin Hooper under 21.5 receiving yards (-110)

Austin Hooper was brought to Tennessee in the offseason to take over as the primary pass-catching tight end, but that wasn’t the case in Week 1. The 27-year-old saw just two targets from Ryan Tannehill and finished the game with one catch for six yards. He was even out-snapped by fellow TE Geoff Swaim, 45-40.

The Titans trust Swaim much more as a run-blocker, so Hooper should see a similar workload in what should be a run-heavy gameplan.

All betting odds courtesy of FanDuel as of 9/19.

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