The NFL Week 1 Injury Report for the 2025 season is live. See which players have already been ruled out below.
NFL Week 1 Injury Report
Christian McCaffrey: "Unfortunately, when you have the injury history that I have, sometimes when you don't practice things get blown out of proportion, but I feel great."
Added that he's proud of himself for shutting it down/playing it safe on Thursday: pic.twitter.com/YPPetvt8rT
— David Lombardi (@LombardiHimself) September 5, 2025
Will Christian McCaffrey play on Sunday? The San Francisco 49ers’ star running back suffered a minor setback in practice on Thursday.
McCaffrey is recovering from a calf/Achilles injury that caused him to miss 13 games in 2024. McCaffrey is listed as questionable on the injury report.
New England Patriots cornerback Christian Gonzalez has already been ruled out for Sunday’s game against the Las Vegas Raiders. Gonzalez is the best Patriots’ defender, so Mike Vrabel will have to plan without his star defensive back in the lineup.
Other notable players on the injury report include Packers pass rusher Micah Parsons (questionable, back), Texans wide receiver Christian Kirk (out, hamstring), and Ravens tight end Isaiah Likely (out, foot).
Friday, Sept. 5 — 8 p.m. ET
Kansas City Chiefs vs. Los Angeles Chargers
CHIEFS
OUT: WR Jalen Royals (knee)
QUESTIONABLE: DL Omarr Norman-Lott (ankle)
CHARGERS
QUESTIONABLE: OL Mekhi Becton (illness)
Sunday, Sept. 7 — 1 p.m. ET
Tampa Bay Buccaneers vs. Atlanta Falcons
BUCCANEERS
OUT: WR Chris Godwin (ankle), OT Tristan Wirfs (knee), CB Benjamin Morrison (quad), S Christian Izien (oblique)
QUESTIONABLE: DT Vita Vea (foot)
FALCONS
OUT: OL Jack Nelson (calf), S DeMarcco Hellams (hamstring)
QUESTIONABLE: WR Darnell Mooney (shoulder)
Cincinnati Bengals vs. Cleveland Browns
BENGALS
No injury designations
BROWNS
OUT: DT Mike Hall (knee)
Miami Dolphins vs. Indianapolis Colts
DOLPHINS
OUT: RB Jaylen Wright (knee), TE Darren Waller (hip), CB Ethan Bonner (hamstring)
QUESTIONABLE: WR D’Wayne Eskridge (concussion), OL James Daniels (ankle)
COLTS
QUESTIONABLE: RB Tyler Goodson (elbow)
Carolina Panthers vs. Jacksonville Jaguars
PANTHERS
OUT: CB Damarri Mathis (knee)
DOUBTFUL: LT Ikem Ekwonu (illness)
JAGUARS
OUT: G Wyatt Milum (knee), CB Montaric Brown (ankle)
QUESTIONABLE: OT Cole Van Lanen (shoulder)
Las Vegas Raiders vs. New England Patriots
RAIDERS
No injury designations
PATRIOTS
OUT: CB Christian Gonzalez (hamstring)
QUESTIONABLE: OT Will Campbell (ankle), CB Charles Woods (groin)
Arizona Cardinals vs. New Orleans Saints
CARDINALS
OUT: G Will Hernandez (knee)
QUESTIONABLE: DT Dante Stills (heel), LB Owen Pappoe (quad)
SAINTS
OUT: OL Trevor Penning (toe), DE Chase Young (calf)
QUESTIONABLE: DB Jordan Howden (oblique)
Pittsburgh Steelers vs. New York Jets
STEELERS
OUT: DL Derrick Harmon (knee)
QUESTIONABLE: QB Skylar Thompson (hamstring), LB Nick Herbig (hamstring)
JETS
OUT: OL Esa Pole (ankle), OL Alijah Vera-Tucker (triceps)
QUESTIONABLE: OL Chukwuma Okorafor (hand)
New York Giants vs. Washington Commanders
GIANTS
DOUBTFUL: OT Andrew Thomas (foot)
COMMANDERS
No injury designations
Sunday, Sept. 7 — 4:05 p.m. ET
Tennessee Titans vs. Denver Broncos
TITANS
DOUBTFUL: S Kevin Winston Jr. (hamstring)
QUESTIONABLE: RB Kalel Mullings (ankle), CB L’Jarius Sneed (knee)
BRONCOS
OUT: TE Nate Adkins (ankle), LB Dre Greenlaw (quad), DT Malcolm Roach (calf)
San Francisco 49ers vs. Seattle Seahawks
49ERS
DOUBTFUL: RB Jordan James (finger), WR Jordan Watkins (ankle)
QUESTIONABLE: RB Christian McCaffrey
SEAHAWKS
OUT: WR Jake Bobo (concussion), WR Dareke Young (hamstring), DL Uchenna Nwosu (knee)
Sunday, Sept. 7 — 4:25 p.m. ET
Detroit Lions vs. Green Bay Packers
LIONS
OUT: Sione Vaki (hamstring), OT Jamarco Jones (ankle), LB Trevor Nowaske (elbow)
PACKERS
QUESTIONABLE: WR Jayden Reed (foot), WR Dontayvion Wicks (calf), WR Savion Williams (hamstring), DL Micah Parsons (back), DL Barryn Sorrell (knee), CB Nate Hobbs (knee), S Zayne Anderson (knee)
Houston Texans vs. Los Angeles Rams
TEXANS
OUT: WR Braxton Berrios (hamstring), WR Christian Kirk (hamstring)
QUESTIONABLE: G Ed Ingram (abdomen)
RAMS
QUESTIONABLE: CB Ahkello Witherspoon (knee)
Sunday, Sept. 7 — 8: 20 p.m. ET
Baltimore Ravens vs. Buffalo Bills
RAVENS
OUT: FB Patrick Ricard (calf), TE Isaiah Likely (foot)
BILLS
DOUBTFUL: CB Tre’Davious White (groin)
Monday, Sept. 8 — 8:15 p.m. ET
Minnesota Vikings vs. Chicago Bears
VIKINGS
TBD
BEARS
TBD
