The NFL Week 6 Injury Report for the 2025 season is live. See which players have already been ruled out below.
NFL Week 6 Injury Report
49ers ruled out QB Brock Purdy and WR Ricky Pearsall for Sunday’s game at Tampa Bay.
49ers QB Mac Jones starts again. pic.twitter.com/7FQglh7QKN
— Adam Schefter (@AdamSchefter) October 10, 2025
A slew of San Francisco 49ers are out against the Tampa Bay Buccaneers, including quarterback Brock Purdy (toe) and wide receiver Ricky Pearsall (knee). Mac Jones will make his fourth start for San Francisco. Jones is 3-0 this season.
Baltimore quarterback Lamar Jackson will miss his second consecutive game with a hamstring injury. At 1-4, the Ravens are fading and in danger of falling too far behind in the playoff picture.
Other notable players on the injury report who have been ruled out include Baltimore linebacker Roquan Smith (hamstring), Dallas wide receiver CeeDee Lamb (ankle), Los Angeles Chargers tackle LT Joe Alt (ankle), and Tampa Bay Buccaneers running back Bucky Irving (foot/shoulder).
Thursday, Oct. 9 — 8:15 p.m. ET
Philadelphia Eagles vs. New York Giants
EAGLES
- OUT: TE Grant Calcaterra (oblique), G Landon Dickerson (ankle)
- QUESTIONABLE: DT Jalen Carter (heel), LB Nakobe Dean (knee)
GIANTS
- OUT: WR Darius Slayton (hamstring), LB Swayze Bozeman (ankle), LB Demetrius Flannigan-Fowles (hamstring)
- QUESTIONABLE: OT Jermaine Eluemunor (back)
Sunday, Oct. 12 — 9:30 a.m. ET
Denver Broncos vs. New York Jets (London)
BRONCOS
- OUT: LG Ben Powers (biceps), OLB Jonah Elliss (ribs/shoulder)
- QUESTIONABLE: DT Malcolm Roach (calf)
JETS
- OUT: WR Allen Lazard (personal), LB Ja’Markis Weston (groin), CB Michael Carter II (concussion)
- QUESTIONABLE: CB Brandon Stephens (neck)
Sunday, Oct. 12 — 1 p.m. ET
Los Angeles Rams vs. Baltimore Ravens
RAMS
- DOUBTFUL: RT Rob Havenstein (ankle), LB Omar Speights (ankle)
- QUESTIONABLE: WR Tutu Atwell (hamstring), TE Colby Parkinson (concussion)
RAVENS
- OUT: QB Lamar Jackson (hamstring), FB Patrick Ricard (calf), OT Emory Jones (shoulder), WR Devontez Walker (oblique), LB Roquan Smith (hamstring), CB Chidobe Awuzie (hamstring)
- QUESTIONABLE: WR Zay Flowers (shoulder)
Dallas Cowboys vs. Carolina Panthers
COWBOYS
- OUT: RB Miles Sanders (knee/ankle), WR CeeDee Lamb (ankle), WR Jonathan Mingo (knee), WR KaVontae Turpin (foot), RG Tyler Booker (ankle), LB Jack Sanborn (concussion), CB Caelen Carson (knee)
- QUESTIONABLE: RT Ajani Cornelius (knees), LG Tyler Smith (knee), DE Marshawn Kneeland (ankle), CB DaRon Bland (shoulder), CB Trevon Diggs (knee)
PANTHERS
- OUT: RB Chuba Hubbard (calf), WR Jalen Coker (quad), RT Taylor Moton (elbow), DT Tershawn Wharton (toe), CB Akayleb Evans (hamstring)
- QUESTIONABLE: TE Ja’Tavion Sanders (ankle), CB Mike Jackson (ribs), CB Chau Smith-Wade (chest)
Arizona Cardinals vs. Indianapolis Colts
CARDINALS
- OUT: DT Darius Robinson (pectoral), DT Bilal Nichols (non-injury related/personal), P Blake Gillikin (back)
- QUESTIONABLE: QB Kyler Murray (foot), WR Zay Jones (knee), LB Cody Simon (knee), LB Mack Wilson (ankle), CB Max Melton (hamstring)
COLTS
- OUT: RB Tyler Goodson (groin), CB Kenny Moore (Achilles)
Seattle Seahawks vs. Jacksonville Jaguars
SEAHAWKS
- OUT: LT Josh Jones (ankle), LB Derick Hall (oblique), CB Tariq Woolen (concussion)
- DOUBTFUL: CB Devon Witherspoon (knee), S Julian Love (hamstring)
JAGUARS
- DOUBTFUL: C Robert Hainsey (hamstring)
- QUESTIONABLE: LB Yasir Abdullah (hamstring)
Los Angeles Chargers vs. Miami Dolphins
CHARGERS
- OUT: WR Derius Davis (knee), LT Joe Alt (ankle), RT Trey Pipkins (knee), DT Da’Shawn Hand (groin)
- QUESTIONABLE: FB Scott Matlock (ankle), WR Quentin Johnston (hamstring), RG Jamaree Salyer (knee), OLB Bud Dupree (hamstring), LB Denzel Perryman (ankle)
DOLPHINS
- OUT: LB Tyrel Dodson (concussion), S Elijah Campbell (quad)
- QUESTIONABLE: C Aaron Brewer (pectoral), CB Storm Duck (ankle)
Cleveland Browns vs. Pittsburgh Steelers
BROWNS
- OUT: DT Michael Hall Jr. (knee)
STEELERS
- OUT: WR Calvin Austin III (shoulder)
New England Patriots vs. New Orleans Saints
PATRIOTS
- OUT: RB Antonio Gibson (knee), DE Keion White (elbow), OLB Anfernee Jennings (ankle), S Jaylinn Hawkins (hamstring)
- QUESTIONABLE: LB Marte Mapu (neck/hamstring), CB Christian Gonzalez (hamstring), CB Charles Woods (knee)
SAINTS
- OUT: CB Isaac Yiadom (hamstring)
- QUESTIONABLE: RB Alvin Kamara (ankle), DT John Ridgeway (shoulder)
Sunday, Oct. 5 — 4:05 p.m. ET
Tennessee Titans vs. Las Vegas Raiders
TITANS
- OUT: WR Bryce Oliver (knee), RG Blake Hance (shoulder), OLB Arden Key (quad), CB Marcus Harris (calf), K Joey Slye (right calf)
- QUESTIONABLE: WR Van Jefferson (ankle), RT JC Latham (hip)
RAIDERS
- OUT: TE Brock Bowers (knee)
- QUESTIONABLE: P AJ Cole (right ankle)
Sunday, Oct. 12 — 4:25 p.m. ET
San Francisco 49ers vs. Tampa Bay Buccaneers
49ERS
- OUT: QB Brock Purdy (toe), WR Ricky Pearsall (knee), WR Jordan Watkins (calf), DL Kevin Givens (pectoral), DL Yetur Gross-Matos (knee/hamstring)
- QUESTIONABLE: QB Mac Jones (knee/oblique), WR Jauan Jennings (ankle/rib), DL Alfred Collins (knee), DL Kalia Davis (hand), CB Upton Stout (ankle), S Malik Mustapha (knee)
BUCCANEERS
- OUT: RB Bucky Irving (foot/shoulder), RB Josh Williams (concussion), WR Mike Evans (hamstring), WR Chris Godwin (fibula), CB Zyon McCollum (thumb), CB Benjamin Morrison (hamstring)
- QUESTIONABLE: DB Christian Izien (quad)
Cincinnati Bengals vs. Green Bay Packers
BENGALS
- DOUBTFUL: RG Lucas Patrick (calf), DE Shemar Stewart (ankle)
- QUESTIONABLE: WR Ja’Marr Chase (illness), LG Dylan Fairchild (knee), C Matt Lee (knee)
PACKERS
- OUT: WR Christian Watson (knee), LT Anthony Belton (ankle), DT Devonte Wyatt (knee)
- QUESTIONABLE: LT Rasheed Walker (quad), RT Zach Tom (oblique/back), LG Aaron Banks (groin/knee), OL Jacob Monk (hamstring), CB Nate Hobbs (concussion), K Brandon McManus (right quad)
Sunday, Oct. 5 — 8:20 p.m. ET
Detroit Lions vs. Kansas City Chiefs
LIONS
- OUT: RB Sione Vaki (groin), LT Taylor Decker (shoulder), LT Giovanni Manu (knee), DT Alim McNeill (knee), LB Zach Cunningham (hamstring), CB Terrion Arnold (shoulder), DB Avonte Maddox (hamstring)
- QUESTIONABLE: WR Kalif Raymond (neck), S Brian Branch (ankle), S Kerby Joseph (knee)
CHIEFS
- No players listed
Monday, Oct. 6 — 7:15 p.m. ET
Buffalo Bills vs. Atlanta Falcons
BILLS
- OUT: LB Matt Milano (pectoral), DT T.J. Sanders (knee), S Damar Hamlin (pectoral)
- QUESTIONABLE: WR Curtis Samuel (neck/ribs), TE Dalton Kincaid (oblique)
FALCONS
- OUT: WR Darnell Mooney (hamstring), DL Ta’Quon Graham (calf), DT LaCale London (triceps), CB Clark Phillips III (triceps/illness)
- QUESTIONABLE: CB Billy Bowman Jr. (knee/hamstring), CB Natrone Brooks (concussion/shoulder)
Monday, Oct. 6 — 8:15 p.m. ET
Chicago Bears vs. Washington Commanders
BEARS
- OUT: DT Grady Jarrett (knee)
- QUESTIONABLE: RB Travis Homer (calf), TE Colston Loveland (hip), DE Austin Booker (knee), K Cairo Santos (right thigh)
COMMANDERS
- OUT: WR Noah Brown (groin/knee), WR Terry McLaurin (quad)
- DOUBTFUL: OL Samuel Cosmi (knee)
- QUESTIONABLE: RB Chris Rodriguez Jr. (calf), WR Deebo Samuel (heel)
