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College Football Week 10: Expert Picks, Predictions, and Best Bets

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College Football Week 10: Expert Picks, Predictions, and Best Bets

College football Week 10 expert picks, predictions, and best bets are back as we gear up for an exciting slate of college football action in Week 10.

As we enter Week 10 of the college football season, the landscape of the sport begins to take shape. Teams that started with promise now face the weight of their aspirations as conference titles loom ever closer.

This week, it’s not just games on the schedule; it’s matchups that carry the gravity of championship dreams and postseason hopes. None looms larger than Penn State vs. Ohio State—a clash of top-5 powers that defines more than just the Big Ten. It’s a game that echoes in the national picture and could shape the College Football Playoff bracket itself.

In a season of stakes, Week 10 feels like a turning point.

We’re fresh off a 2-1 Week 9! 

Check out our Week 10 Expert picks and best bets!

College Football Week 10 Expert Picks and Best Bets

Minnesota vs. Illinois Betting Preview and Expert Pick

All Minnesota vs. Illinois odds are from DraftKings Sportsbook and are correct as of Wednesday, Oct.30.

  • Spread
    Minnesota -3
  • Moneyline
    Minnesota -145, Illinois +120
  • Over/Under
    45.5
  • Game Time
    Noon ET
  • Location
    Memorial Stadium | Champaign, IL
  • Predicted Weather at Kick
    53 degrees, mostly cloudy
  • How To Watch
    FS1

The #24 Illinois Fighting Illini welcome the surging Minnesota Golden Gophers on Saturday for an afternoon Big Ten clash, where both teams bring renewed purpose to the field. For Minnesota, after three consecutive wins, there’s a new sense of possibility. While a Big Ten title remains unlikely, the Gophers have positioned themselves to make noise with upcoming battles against Penn State and Wisconsin and a crucial visit to Rutgers.

Illinois’s season remains bright despite a tough loss to Oregon. Already bowl eligible, Illinois now faces a favorable stretch: three of their last four games are in Illinois, with matchups against Michigan State, Rutgers, and Northwestern. This could be a path for them to close the season strong.

Minnesota’s Max Brosmer has been a revelation, posting 1,776 yards and a 12-4 touchdown-to-interception ratio. Luke Altmeyer of Illinois, with 15 touchdowns and three interceptions on the season, struggled last week with two picks and fewer than 200 passing yards against Oregon. For the Illini defense, third downs have been a persistent challenge, leaving room for the Gophers’ efficient formula.

Minnesota’s game plan? Convert on third downs and maintain dominance in the turnover battle. They’re +7 in turnovers over their three-game winning streak with just one giveaway. If they can keep that discipline, the Gophers have a chance to carry their hot streak into Memorial Stadium and beyond.

Prediction: Minnesota 24 – Illinois 20

Best Bet: Minnesota -3

Ohio State vs. Penn State Betting Preview and Expert Pick

All Ohio State vs. Penn State odds are from DraftKings Sportsbook and are correct as of Wednesday, Oct.30.

  • Spread
    Ohio State -3.5
  • Moneyline
    Ohio State -170, Penn State +140
  • Over/Under
    45.5
  • Game Time
    Noon ET
  • Location
    Beaver Stadium | University Park, PA
  • Predicted Weather at Kick
    50 degrees, mostly cloudy
  • How To Watch
    FOX

As noon approaches on Saturday in State College, all eyes turn to a storied Big Ten clash: Ohio State vs. Penn State. The Buckeyes are fresh off a 21-17 grind over Nebraska, while the Nittany Lions flexed their muscles last week in a 28-13 victory over Wisconsin. Ohio State has dominated this rivalry, winning 11 of the last 12 games, yet the battles are closer than the record shows—the Buckeyes are just 2-5 against the spread over that stretch.

Memories linger of their last visit to Happy Valley in 2022 when Penn State led 21-16 with nine minutes left, only for Ohio State to erupt for 28 points, sealing a 44-31 win. Now, the Buckeyes arrive with a defense that ranks second nationally, allowing fewer than 12 points per game. Since 2022, only Michigan and Oregon have broken that 17-point ceiling against this OSU defense.

For Penn State, uncertainty looms around star QB Drew Allar’s injury status, leaving sophomore Beau Pribula as a potential starter. Pribula impressed last week, completing 85% of his passes and adding a versatile run threat. With a week to prepare, Ohio State’s defense will be primed for either QB.

Penn State’s offense has stumbled in high-stakes moments, with tight games against Illinois and USC. Meanwhile, Buckeye quarterback Will Howard has been a steady presence, and with a well-prepared Ohio State defense, don’t expect a high-scoring affair.

It won’t be flawless but expect an efficient, resilient Buckeyes victory.

Prediction: Ohio State 27 – Penn State 13

Best Bet: Ohio State -3.5

Texas A&M vs. South Carolina Betting Preview and Expert Pick

All Texas A&M vs. South Carolina odds are from DraftKings Sportsbook and are correct as of Wednesday, Oct.30.

  • Spread
    Texas A&M -3
  • Moneyline
    Texas A&M  -135, South Carolina +115
  • Over/Under
    44.5
  • Game Time
    7:30 p.m. ET
  • Location
    Williams-Brice Stadium | Columbia, SC
  • Predicted Weather at Kick
    74 degrees, mostly cloudy
  • How To Watch
    ABC

In a season where storylines abound, one stands out in the SEC: the unbeaten streak of Texas A&M. The Aggies, fresh off a decisive win over LSU, have strung together seven consecutive victories, standing as the lone undefeated in SEC conference play. But this Saturday, they face a real test as they head to Williams-Brice Stadium to take on South Carolina, a team no stranger to adversity.

The Gamecocks, underdogs by three points on their home turf, come off a bye and carry with them a chance to reshape the SEC landscape. Their season may seem modest at 4-3, but their losses—to LSU, Ole Miss, and Alabama—reflect a gauntlet of tough competition. Last week, they made a statement on the road with a dominant 35-9 win over Oklahoma.

At the heart of South Carolina’s challenge is their defense, ranked among the nation’s best, particularly against the run. Allowing just 101.9 yards per game on the ground and a stingy 2.8 yards per carry, the Gamecocks’ front seven is poised to be a wall against the Aggies’ ground game. Texas A&M, with a passing attack that’s yet to fully click, faces an uphill battle against South Carolina’s 37th-ranked pass defense.

Under the lights in Columbia, it’s a matchup with high stakes, where the Gamecocks just might hand Texas A&M their first SEC loss of the season.

Prediction: South Carolina 24 – Texas A&M 20

Best Bet: South Carolina +3