Sunday Night Football in Week 5 features the New England Patriots (2-2) taking on the Buffalo Bills (4-0). Here are the odds, predictions, and free expert picks for Patriots vs. Bills.
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Patriots vs. Bills: Game Information
Waiting all week for Sunday night. pic.twitter.com/BPc0GNGVM8
— New England Patriots (@Patriots) October 1, 2025
- 🏈 Game: Patriots vs. Bills
- 🗓️ Date: Oct. 5
- 🕗 Time: 8:20 p.m. ET
- 🏟 Location: Highmark Stadium — Orchard Park, New York
- 📺 TV Channel: NBC
- 💻 Live Stream: Peacock, NFL+
Patriots vs. Bills Odds and Predictions
❄️ WHITE OUT ALERT ❄️#BillsMafia | More info: https://t.co/YBgz7FXIc9 pic.twitter.com/jH3btn3DAT
— Buffalo Bills (@BuffaloBills) September 30, 2025
The New England Patriots are starting to turn some heads in NFL circles.
Drake Maye is off to a fantastic start in his second year. Maye ranks fifth in passer rating (109.4), sixth in passing yards (988), and tied for eighth in passing touchdowns (7).
Maye threw for 203 yards and two touchdowns in New England’s 42-13 win over the Carolina Panthers.
The Patriots’ defense received a huge boost with the return of cornerback Christian Gonzalez. However, New England’s pass defense is still struggling — 27th in EPA per dropback and 29th in opponent success rate per pass.
You play who is on the schedule, and the Patriots have two wins over below .500 teams — Panthers and Dolphins.
The Bills are one of the top teams in the AFC and will be a step up in competition for the Patriots.
The Bills’ offense is humming to start 2025 — second in yards (404.0) and scoring (33.3) per game. Buffalo is doing this with average play from Josh Allen. That is a compliment to Buffalo’s offense because it shows they can win games and score 30 points without Allen being Superman.
If the Patriots somehow win this game, they will earn the respect of the entire NFL. However, Buffalo remains at the top of the class. This is a game where they flex their firepower.
Pick: Bills -9 (+100)
Patriots vs. Bills Prop
Allen doesn’t have to wear the cape, but that doesn’t mean he has to leave it in the closet.
Allen has thrown at least two touchdown passes in three of four games.
The MVP has hit the passing touchdown over in 13 of his last 19 games. Allen should have a big statistical night.
