Monday Night Football in Week 5 pits the Kansas City Chiefs (2-2) against the Jacksonville Jaguars (3-1). Here are the odds, predictions, and free expert picks for Chiefs vs. Jaguars.
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Chiefs vs. Jaguars: Game Information
Play "Night Prowler" by AC/DC@SherwinWilliams | #KCvsJAX pic.twitter.com/XN3vpaUUIe
— Jacksonville Jaguars (@Jaguars) October 2, 2025
- 🏈 Game: Chiefs vs. Jaguars
- 🗓️ Date: Oct. 6
- 🕗 Time: 8:15 p.m. ET
- 🏟 Location: EverBank Stadium — Jacksonville, Florida
- 📺 TV Channel: ESPN, ABC
- 💻 Live Stream: NFL+
Chiefs vs. Jaguars Odds and Predictions
Decades of matchups with the Jags. pic.twitter.com/mkFvtAMkyF
— Kansas City Chiefs (@Chiefs) October 2, 2025
Have the Kansas City Chiefs fixed their woes? For the first 10 quarters of the season, the Chiefs did not look like a perennial AFC power.
In the last six quarters, Patrick Mahomes and this offense have outscored their opponents 50-23. Speaking of Mahomes, the two-time MVP looks like himself again after a four-touchdown performance in the 37-20 win over the Baltimore Ravens.
Xavier Worthy returned to the lineup last week, and it made all the difference. Worthy caught five passes for 83 yards and rushed the ball twice for 38 yards. With Worthy in the lineup, this Chiefs’ offense is more dynamic, and it will only get better when Rashee Rice returns in Week 7.
The Jaguars are one of the surprises of 2025. This defense is a takeaway machine, with a league-best 13 forced turnovers. If Jacksonville continues to win the turnover battle, it will win many more games.
The other surprise has been the rebirth of the running game. Travis Etienne Jr. is third in the NFL with 394 yards rushing, and the Jaguars rank fourth in rushing yards per game (144.0).
The Jaguars are winning games despite Trevor Lawrence, who ranks 21st in QBR at 49.0. Good luck facing Steve Spagnuolo’s defense.
Brian Thomas Jr. and Travis Hunter are also off to slow starts, making the team’s record that much more impressive.
This game comes down to turnovers. If Kansas City turns the ball over, it will lose. If Mahomes takes care of the ball, the Chiefs win.
Mahomes is 5-0 against the Jaguars. If he wins on Monday, he moves to 6-0, his best record against any team. Look for Mahomes to get that sixth win.
Pick: Chiefs -3.5 (-105)
Chiefs vs. Jaguars Prop
If you think the Chiefs are going to win and cover, Mahomes will need to take care of the ball.
Mahomes has one interception this season, which came in Week 2 against the Eagles.
Mahomes is the smartest quarterback in the NFL. He knows the Jaguars will be super aggressive in the secondary. Expect a surgical Mahomes to get the ball out of his hands and make accurate throws to leave the game without an interception.
