Leyton Orient vs Manchester City Preview, Prediction, Team News and Confirmed Lineups

Manchester City head to East London to take on League One side Leyton Orient in the FA Cup fourth round on Saturday, and we’ve got the latest team news and confirmed lineups included in our preview.

Leyton Orient vs Manchester City Preview

Fresh off the back of being battered 5-1 by Arsenal in the Premier League on Sunday, Manchester City return to action on Saturday with an FA Cup fourth round clash against League One promotion-chasers Leyton Orient.

City had won back-to-back matches against Chelsea and Club Brugge prior to the damaging defeat to the Gunners, and they now find themselves in fifth place in the English top-flight table, 15 points adrift of league leaders Liverpool and two points outside of the top four.

Of course, the Cityzens reached the FA Cup final last term, where they lost to local rivals Manchester United. They enter the fourth round having beaten League Two side Salford City 8-0 in the third round last month.

Straight into it 🏃#LOFC #OneOrient pic.twitter.com/NKkbpKBvul

— Leyton Orient FC (@leytonorientfc) February 4, 2025

The O’s, meanwhile, are currently in the play-off positions, occupying sixth place in the third tier, and they come into this one having suffered a narrow 1-0 defeat to Stockport County at the weekend. Subsequently, that result ended their 11 game unbeaten run in the league.

Richie Wellens’ side, who reached the second round last term, beat Boreham Wood, Oldham Athletic and Derby County on their way to the fourth round, overcoming the latter on penalties in the third round.

Orient’s best-ever finish in the competition came in the 1977/78 season, when they beat Norwich, Blackburn, Chelsea and Middlesbrough on their way to the semi-finals as a second-tier side, before being eliminated by Arsenal.

In terms of previous meetings between Leyton Orient and Manchester City, they have faced off a total of 16 times, with City claiming 12 victories, the O’s winning two, and two ending in stalemates. Their most recent clash came in the second division in 1966, which ended in a 2-2 draw.

Leyton Orient Team News

The hosts are likely to be without Sean Clare and Omar Beckles due to their respective injury concerns, while Jordan Graham, Dan Agyei, Jack Simpson and Ollie O’Neill are also expected to miss out.

Manchester City Team News

As for the Cityzens, Ederson (fitness) and Oscar Bobb (leg) could make their returns from injury, while Jeremy Doku (unspecified), Nathan Ake (muscular) and Rodri (knee) are ruled out.

January signings Abdukodir Khusanov and Vitor Reis could start in central defence after being confined to the bench at the weekend, while Nico O’Reilly, Rico Lewis, Jack Grealish and Ilkay Gundogan are also in contention for starts.

Leyton Orient vs Manchester City Predicted Lineups

Leyton Orient Predicted Lineup:

Keeley; James, Simpson, Happe, Currie; Galbraith, Brown; Perkins, Donley, Jaiyesimi; Kelman

Manchester City Predicted Lineup:

Ortega; Lewis, Reis, Dias, O’Reilly; Gundogan, Gonzalez; Savinho, McAtee, Grealish; Marmoush

Leyton Orient vs Manchester City Prediction

Unsurprisingly, Manchester City are heavily favoured to come out on top on Saturday by the UK’s best football betting sites at odds of 1/10, while a draw is valued at 10/1 and a Leyton Orient win is priced at 18/1.

Despite their heavy defeat at the weekend and Orient’s impressive form in the third tier this term, we at SportsCasting agree with the bookmakers and are backing Pep Guardiola’s side to claim a comfortable victory on the road.

Prediction: Leyton Orient 0-3 Manchester City